Driving real, measurable and successful outcomes.

Multiple Sclerosis (MS) is a disease that damages and destroys the myelin sheath that insulates and protects the bundles of nerve fibres or axons that carry signals between the brain, spinal cord and the rest of the body.

An initial destruction of myelin leads to a secondary inflammatory cascade that alters the normal CNS landscape dramatically. This new “tissue microenvironment”, inhibits the normal remyelination capacity of the nervous syetem and leads to degeneration of the nerve fibre (axon).

Crucially, rebuilding myelin provides a nurturing healthy environment for the nerve, prevents degeneration and ultimately restores function.

Our work is focused on developing treatments that rebuild myelin. This means rather than just halting the progression of the disease, for the first time we may be able to actually restore neuron function in neuro-degenerative diseases like; Multiple Sclerosis, ALS, Neuromyelitis Optica, Stroke and Alzheimer’s.

Purkinje Neurons (red). Demyelination in MS results in loss of or diminished control of movements of muscle groups needed to throw a ball, thread a needle, or drink form a glass of water.